A Comparison of Spectinomycin with Ceftriaxone as Treatment for Uncomplicated Gonorrhea

نویسندگان

چکیده

Objective: To compare the efficacy of spectinomycin with ceftriaxone as treatment for Uncomplicated Gonorrhea. Design Study: It was a cross-sectional survey. Place and Duration This study carried at Department Pharmacology DHQ Teaching Hospital kohat Khaleefa Gul Nawaz Bannu from March 2019 to march 2020. Patients Methods: For trial, 200 participants were enrolled. Two groups 100 patients each formed by randomly dividing patients. Injections (2 gm) (500 mg) administered intramuscularly Group A B, respectively. After 5 days, all underwent reexaminations, their clinical laboratory results noted reviewed. Results When spectinomycin, in (n = 100) indicated 95% full response, 3% partial 2% no reaction, but when given ceftriaxone, B 91% 6% response all. Furthermore, aetiology gonorrhoea infection is not statistically associated getting older. Conclusion: The cure rates are indistinguishable. However, may only be used cases resistance because it causes pain injection site, less effective pharyngeal gonorrhoea, contraindicated during pregnancy breast-feeding. Keywords: Neisseria Gonorrhea, Ceftriaxone, Spectinomycin

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea.

Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) ...

متن کامل

Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women.

Although women bear the brunt of gonococcal infection-related morbidity, few large studies of gonorrhea treatment in women have been conducted. In a multicenter, double-blind, placebo-controlled trial, 181 evaluable women with uncomplicated gonorrhea were treated with ciprofloxacin (250 mg orally; 94 women) or ceftriaxone (250 mg intramuscularly; 87 women). Twenty-four percent of the participan...

متن کامل

Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men.

Uncomplicated gonorrhea in men was successfully treated with ceftriaxone in single intramuscular doses of 125 mg (15 patients), 250 mg (16 patients), or 500 mg (15 patients). All 45 pretreatment gonococcal isolates tested were inhibited by </=0.016 mug of ceftriaxone per ml. Treatment was well tolerated and caused no toxicity.

متن کامل

Comparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men.

Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgr...

متن کامل

[Spectinomycin in the treatment of gonorrhea].

To the editor: We have read with interest the recent paper by Kubanova et al. in which they recommend the use of spectinomycin in case of difficulty to access ceftriaxone or in the presence of severe beta-lactam antimicrobial allergy [1]. Although we agree with most of the conclusions we would like to warn about the potential risks in cases of pharyngeal gonorrhoea. Spectinomycin is an aminogly...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Pakistan Journal of Medical and Health Sciences

سال: 2022

ISSN: ['1996-7195']

DOI: https://doi.org/10.53350/pjmhs22168587